Development of a mouse computational model for MCNPx based on Digimouse® images and dosimetric assays
نویسندگان
چکیده
The aim of this study was to create and test a new mice 3D-voxel phantom named DM_BRA for mice and human first-estimation radiopharmaceutical dosimetry. Previously, the article reviews the state-ofart in animal model development. Images from Digimouse CT database were used in the segmentation and on the generation of the voxelized phantom. Simulations for validation of the DM_BRA model was performed at 0.015, 0.1, 0.5, 1 and 4 MeV photons with heart-source. Specific Absorbed Fractions (SAF) data were compared with literature data. The organ masses of DM_BRA correlated well with existing models based on the same dataset; however, few small organ masses hold significant variations. The SAF data in most simulated cases were statistically equal to a significant level of 0.01 to the reference data.
منابع مشابه
Development of a Liver Phantom Based on Computed Tomography Images for Dosimetric Purpose
Introduction: The present study was conducted with the aim of designing a liver phantom for dosimetry. To benchmark the results obtained by the developed liver phantom, another method was applied for the dosimetry of a real liver tissue using imaging. Materials and Methods: For the purpose of the study, a real liver tissue was converted into a phantom based on thegram-molecular weight of the co...
متن کاملCalculation the accumulated dose in the heart and its effect on other human organs by using experimental mouse data and the MCNPX code for FDG
Introduction: The use of ionizing radiation in diagnostic medicine is expanding, and considering the fact that the practical dosimeter in a precise way is almost impossible, the Monte Carlo computational methods help researchers, to have coming up the lowest cost and error of the distribution of doses in the patient's body. Materials and Methods: In this st...
متن کاملDevelopment of a free anthropomorphic voxel model of human body for wide-band computational electromagnetics dosimetry
To calculate and evaluate wave scattering and penetration of electromagnetic waves in different biological tissues it is necessary to use a realistic model of the human body, with all tissues resolved and separately assigned with appropriate electric/magnetic properties. We report the development of a realistic 3D whole-body human model that has been adapted for simulation in CST software, cont...
متن کاملیک فانتوم سر ریاضیاتی برای بررسیهای دوزیمتری به روش مونتکارلو
Introduction: In diagnostic and therapeutic procedures, dosimetric studies are performed on the dosimetric systems in order to comply the radiation safety standards. Monte Carlo methods are used due to the high complexity and cost of patient-specific phantom construction. The high complexity of the digitized phantoms greatly increases the time and computational task of the Monte Carlo calculati...
متن کاملDetermination of TG-43 Dosimetric Parameters for Photon Emitting Brachytherapy Sources
Objective: Brachytherapy sources are widely used for the treatment of cancer. The report of Task Group No. 43 (TG-43) of American Association of Physicists in Medicine is known as the most common method for the determination of dosimetric parameters for brachytherapy sources. The aim of this study is to obtain TG-43 dosimetric parameters for 60Co, 137Cs, 192Ir and 103Pd brachyt...
متن کامل